CCR5 Delta 32 Deletion Mutation, HIV and AIDS infections. by James Arjuna

The Evodelusionists think that the CCR5-Δ32 deletion is a beneficial mutation.  OMG!

The CCR5-Δ32 Is a DELETION of important immune system proteins. These proteins are on the surface of immune cells and allows the cell to perform its duty to protect you from diseases and cancer.
It acts as a receptor for chemokines.  It is also the protein that the HIV virus likes and uses as a way to enter into cells.

Watch this video. It clearly demonstrates how virus enter cells and mutate them.  And shows the reason why humans are degrading so rapidly today and now have 8000 congenital and birth defects. With this going on all the time, we need to do something about it.

What is HIV and Retrovirus

Keep in mind that these people believe in evolution and that screws up much of their interpretation of what they think is going on. They can only really test the DNA strands and see the insertion of the viral imprint on the DNA. the rest they are not sure about, but is a good guess. 

When is HIV turning into AIDs.

The lack of this protein made in the CCR5,  leaves the immune system lacking abilities to ward off infections.

It turns out that HIV is a virus that is attracted naturally to this protein and uses it to gain access to the immune cell and replicate itself as a retrovirus throughout the human body's immune cells. HIV is an infection of the immune system. It is the worst infection humans have ever seen, because the body's immune system used to fight off infection IS INFECTED.  So it will not attack immune cells and destroy them because they are the immune cells! So if you do not have the protein the CCR5 Delta 32 cannot make because it is gone, the HIV has no "landing point" in our bodies rendering those with this deletion "immune" to HIV.

Remember we talked about how certain viruses are attracted to certain cells of the body and that virus are transmitted from one creature to another because of  activity in which the creatures have similar proteins and similar DNA with which these viruses are attracted to and can penetrate as in this video.  Once the virus enters a cell it basically mutates it screws up the DNA as you can see and causes diseases. This can be avoided by not cultivating animals for food and NOT eating Chimpanzees in the case of HIV which is a mutated SIV we got from Chimps.  Eating meat is a dangerous thing. Transmitting viruses from one human to another in a sexual activity is dangerous also.  There is only one cure* for this.

This is why humans have so many diseases. We infect our reproductive cells with these viruses by not following any healthy sexual behavior.  We can see this by the rampant rise in STD's caused by the religion of Evodeluionsism. 

ERV's

There have been found over 98000 ERV's in humans; some have more some have less (endogenous retrovirus). These represent infections a the germ line (reproductive cells egg sperm or first zygote cells) level that have done this "reverse transcriptase" to other cells. Infections at the germ line level cause fetal permanent deleterious mutations. The virus cannot enter and become part of the cell without destroying its healthy functions. The DNA is permanently screwed up and damaged on any cell with a retrovirus. The molecular path of our genetic degradation is mapped clearly in these ERVs which are found in DNA coding for diseases tissues and gene losses, atavism.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521986/

All we see in humans is a contiual genetic loss of health and fitness from this process of genetic suicide by not following any of the rules we were given for life. Read the linked article:

http://evolutionsciencenow.blogspot.com/2013/04/are-humans-getting-better-what-is.html

What people have realized that this deleterious CCR5-Δ32 deletion mutation of gene LOSS basically does not allow HIV virus to have an entry point.


It does however destroy important immune functions and so it is part of 10 or more different genetic diseases. I have found these so far.

It causes death in H1N1 cases and in West Nile Virus because the body's immune system is greatly diminished by this:

Detrimental for Flu patients and it kills:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0053515

Characterization In Vitro and In Vivo of a Pandemic H1N1 Influenza Virus from a Fatal Case

In addition, examination of chemokine receptor 5 (CCR5) genotype, recently reported as involved in severe influenza virus disease, revealed that the F virus-infected patient was homozygous for the deleted form of CCR5 receptor (CCR5Δ32).

The chemokine receptor CCR5 is expressed on activated macrophages and plays an important role in the macrophage response to influenza virus infection since knock out mice for Crc5 gene display increased mortality rates [37]. Moreover, critically ill patients infected with pandemic H1N1 virus showed a large proportion of heterozygosity for a deleted allele of CCR5 that prevents the surface expression of the protein (CCR5Δ32)

Diabetes:
Therefore the F patient was infected with a potential highly pathogenic virus and its genetic background of CCR5Δ32 homozygous could contribute to the severity of the infection.

It is found in cases of diabetes:
Risk of Diabetic Nephropathy in Type 1 Diabetes Is Associated With Functional Polymorphisms in RANTES Receptor Gene (CCR5)
A Sex-Specific Effect
Wojciech M. Mlynarski123, Grzegorz P. Placha12, Pawel P. Wolkow12, Jacek P. Bochenski12, James H. Warram1 and Andrzej S. Krolewski12

"Similarly, male carriers of the 32-bp deletion, which causes truncation of the protein, had significantly higher risk of diabetic nephropathy than noncarriers"

Hepatitis:
Genetics in Medicine (2004) 6, 126–131; doi:10.1097/01.GIM.0000127274.45301.54 neo
Hepatitis B patients have serious problems with this deletion:
"Most adults infected with hepatitis B virus (HBV) recover and develop protective antibodies. However, approximately 5 per cent of adults remain chronically infected with HBV and are at risk for developing end-stage liver disease and hepatocellular carcinoma [1] . Chemokine receptor 5 (CCR5) is a gene located on short (p) arm at position 21 on chromosome [2] . CCR5 is critical in regulating T cell functions by mediating recruitment, polarization, activation and differentiation of type 1 cytokine secreting T helper and cytotoxic T cells. A 32 bp deletion in the coding region of CCR5 gene leads to complete loss of the functional CCR5 protein synthesis."

"The overall allele frequency of CCR5∆32 for all study subjects was 11.11 per cent, which is consistent with an earlier study [4] . Woitas and group [8] have shown that homozygosity for 32 bp deletions is also more common in HCV infected patients than in healthy controls; they have shown that patients with 32 bp mutation have elevated viral loads".
Goel V, Bose PD, Sarma MP, Hazam RK, Das BC, Gondal R, Kar P. Chemokine receptor 5 (CCR5) polymorphism in chronic hepatitis B patients treated with three different nucleos(t)ide analogues . Indian J Med Res [serial online] 2013 [cited 2013 Jul 12];137:1208-9. Available from: http://www.ijmr.org.in/text.asp?2013/137/6/1208/114396

It is found in Prostate cancer patients:
Association of Polymorphisms in MCP-1, CCR2, and CCR5 Genes with the Risk and Clinicopathological Characteristics of Prostate Cancer
To cite this article:
Canan Kucukgergin, Ferruh K. Isman, Bedia Cakmakoglu, Oner Sanli, and Sule Seckin. DNA and Cell Biology.
" CCR5 Δ32/wt genotype and CCR5 Δ32 allele were also found to be involved in the susceptibility to prostate cancer"


Breast Cancer:
"CCR5 Expression Influences the Progression of Human Breast Cancer in a p53-dependent Manner
Santos Mañes 1 , Emilia Mira 1 , Ramón Colomer 2 , Sagrario Montero 2 , Luis M. Real 4 , Concepción Gómez-Moutón 1 , Sonia Jiménez-Baranda 1 , Alfredo Garzón 3 , Rosa Ana Lacalle 1 , Keith Harshman 1 , Agustín Ruíz 4 , and Carlos Martínez-A. 1"

Cancer seriously needs a good immune system. It is an immune deficiency disease and we know that people with strong healthy immune systems don't get cancer.
You can see how cancer cells are destroyed by the immune system in this video. It is not good to remove immune function by this CCR5 32 base pair deletion.
https://www.youtube.com/watch?v=YJSrxzatNzY


It is found in Schizophrenia;
Association Between the CCR5 32-bp Deletion Allele and Late Onset of Schizophrenia
Henrik Berg Rasmussen; Sally Timm; August G. Wang; Karen Søeby; Henrik Lublin; Mogens Fenger; Ralf Hemmingsen; Thomas Werge
Am J Psychiatry 2006;163:507-511. 10.1176/appi.ajp.163.3.507"

I speculate this is because of damage to the brain cells from infections that were not stopped by these immune cells without this receptor protein.

It is found in Multiple Sclerosis in several studies. 

 MS is a horrible disease.
"Association of CCR5 Δ32 deletion with early death in multiple sclerosis
Radhika Gade-Andavolu1, David E Comings2, James MacMurray2, Masoud Rostamkhani2, Li S -C Cheng3, Wallace W Tourtellotte4 and Lawrence A Cone1,5
1Genetic Research Institute of the Desert, Eisenhower Medical Center, Rancho Mirage, California
2Department of Medical Genetics, City of Hope Medical Center, Duarte, California
3Department of Bio statistics, City of Hope Medical Center, Duarte, California"

"Neurology & Research Services, VA, West Los Angeles Healthcare Center & Department of Neurology, UCLA, Los Angeles, California
5Sections of Immunology and Infectious Diseases, Eisenhower Medical Center, Rancho Mirage, California"

"Cell Mol Neurobiol. 2009 Dec;29(8):1205-9.
CCR5-delta 32 allele is associated with the risk of developing multiple sclerosis in the Iranian population.
Shahbazi M, Ebadi H, Fathi D, Roshandel D, Mahamadhoseeni M, Rashidbaghan A, Mahammadi N, Mahammadi MR, Zamani M.
Source
Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. shahbazimajid@yahoo.co.uk"

Genetics in Medicine (2004) 6, 126–131; doi:10.1097/01.GIM.0000127274.45301.54

Association of CCR5 Δ32 deletion with early death in multiple sclerosis

Radhika Gade-Andavolu1, David E Comings2, James MacMurray2, Masoud Rostamkhani2, Li S -C Cheng3, Wallace W Tourtellotte4 and Lawrence A Cone1,5

1Genetic Research Institute of the Desert, Eisenhower Medical Center, Rancho Mirage, California
2Department of Medical Genetics, City of Hope Medical Center, Duarte, California
3Department of Bio statistics, City of Hope Medical Center, Duarte, California
4Neurology & Research Services, VA, West Los Angeles Healthcare Center & Department of Neurology, UCLA, Los Angeles, California
5Sections of Immunology and Infectious Diseases, Eisenhower Medical Center, Rancho Mirage, California
Correspondence: Dr. Lawrence A. Cone, >39000 Bob Hope Drive, Eisenhower Medical Center, Probst # 308, Genetic Research Institute of the Desert, Rancho Mirage, CA 92270.

Abstract
The 32-base pair deletion on the C-C chemokine receptor 5 gene (CCR5-delta 32) is known as a protective allele against immune system disorders. We have studied this variation in Iranian multiple sclerosis (MS) patients and healthy controls. DNA samples were prepared from the whole blood of 254 patients with MS and 380 healthy controls. We amplified the fragment including the CCR5-delta 32 polymorphism and visualized the products in a documentation system after agarose gel electrophoresis. Data were analysed using one-way ANOVA and Fisher's exact tests with SPSS-v13 and STATA-v8 software. The delta 32 allele was more frequent in MS patients when compared with controls (OR = 2.3, P < 0.0001). Also, we found a significant difference in the frequency of the delta 32/delta 32 genotype among patients and controls (OR = 7.4, P < 0.001). The mean age at onset and progression index was not significantly different between patients with various genotypes. According to our study, the delta 32 allele of the CCR5 gene might be a predisposing factor for MS development in the Iranian population. However, there were no associations between this polymorphism and the clinical course of the disease in this study."

It is found as a part of sudden rupture in aortic aneurisms:
"In patients with abdominal aortic aneurysm (AAA), the major risk is a sudden rupture - which is quite often fatal. Individuals with the delta 32 variant are more likely to have aneurysms than non-carriers, and among patients with aneurysms, delta 32 carriers are more likely to rupture than to be diagnosed in time for surgical repair. [PMID 15557916]"

The CCR5 Delta 32 base pair deletion is a removal of important immune DNA. Therefore it does not fit the criteria of adding genes.

A DELETION REMOVES GENE FUNCTION!

Here's More:

Atopic Asthma:
http://www.ncbi.nlm.nih.gov/pubmed/23454776

"MCP-1, CCR2 and CCR5 Polymorphisms
in Tunisian Patients with Atopic Asthma
Tarak Dhaouadi1, Imen Sfar1, Hajer Aounallah-Skhiri2, Saloua Jendoubi-Ayed1,
Hend Bouacha3, Taieb Ben Abdallah1, and Yousr Gorgi1
1Laboratory of Research in Immunology of Renal Transplantation and Immunopathology,
Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia
2National Institute of Public Health, Tunis, Tunisia
3Pneumonology Department, Charles Nicolle Hospital, Tunis, Tunisia
Received: 3 November 2011; Received in revised form: 8 May 2012; Accepted: 8 August 2012"

More on MS:

Genetics in Medicine (2004) 6, 126-131; doi:10.1097/01.GIM.0000127274.45301.54

Association of CCR5 Ä32 deletion with early death in multiple sclerosis

Radhika Gade-Andavolu1, David E Comings2, James MacMurray2, Masoud Rostamkhani2, Li S -C Cheng3, Wallace W Tourtellotte4 and Lawrence A Cone1,5

1Genetic Research Institute of the Desert, Eisenhower Medical Center, Rancho Mirage, California
2Department of Medical Genetics, City of Hope Medical Center, Duarte, California
3Department of Bio statistics, City of Hope Medical Center, Duarte, California
4Neurology & Research Services, VA, West Los Angeles Healthcare Center & Department of Neurology, UCLA, Los Angeles, California
5Sections of Immunology and Infectious Diseases, Eisenhower Medical Center, Rancho Mirage, California
Correspondence: Dr. Lawrence A. Cone, >39000 Bob Hope Drive, Eisenhower Medical Center, Probst # 308, Genetic Research Institute of the Desert, Rancho Mirage, CA 92270.

The CCR5 Delta 32 is obviously not a good nor beneficial mutation.

The only disease it helps is Rheumatoid Arthritis, because it does the same a s Viox did that killed people. It removes immune functions and the immune system in Rheumatoid Arthritis is so screwed up from mutations it can't recognize "self vs not self" cells so it believes joints are infections and is constantly trying to kill the joints as if they were pathogens.  So, if you don't need your immune system then this is a "beneficial" mutation.  NOT! It is ridiculous stretch of the imagination by these religious believers in evolution.

footnotes:

*  http://www.guardian.co.uk/society/2010/aug/25/sexually-transmitted-infections-hit-record-high

Pay close attention to this statement and really think about it:

In less than 2 generations 30-40 years every STD we have today can be wiped off the earth if people were moral and followed the laws of Science about virgin marriage to a clean, non-diseased,  mate and absolutely no infidelity, no anal sex, no french kissing of infected people, no sharing of diseases ever.  Stop transmitting human virus to animals and sending them back to us mutated to further destroy human life. Stop eating meat which is a known poison to humans.

 "We don't believe in making young girls and women into sluts and whores as being a "good" thing. We believe that women should be honored as the mothers of the future rather than the incubators of fetal mutants." JA

More on the CCR5 Delta 32

The CCR5 Delta 32 DELETION of immune proteins is bad and has always been bad for people fighting any infection needing fully functioning immune cells.



When HIV patients are given immune cell inhibitors to reduce the AID's it also leaves them prone to die from other infections.


Consider that there are so many forms of degraded mutations in modern humans it is very difficult to isolate causes. So, we look at many studies on the same subject to draw conclusions. The CCR5 Delta 32 is a bad mutation that is associated with suffering and death in over 20 diseases that have been studied so far.


http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0106424

Clinical Significance of the CCR5delta32 Allele in Hepatitis C

Isabelle Morard mail, Sophie Clément, Alexandra Calmy, Alessandra Mangia, Andrea Cerny, Andrea De Gottardi, Meri Gorgievski, Markus Heim, Raffaele Malinverni, Darius Moradpour, Beat Müllhaupt, David Semela, Stéphanie Pascarella, Pierre-Yves Bochud, Franco Negro,
on behalf of the Swiss Hepatitis C Cohort Study Group


"In conclusion, our results, based on a large cohort of 1,450 HCV-infected patients, genotyped for the CCR5delta32 allele and representative of the distribution of this allele in a Caucasian population, showed that that both IFNL3 rs1297860 CT/TT and CCR5delta32 alleles were associated with a decreased spontaneous HCV clearance, although the multivariate analysis barely failed to reach statistical significance for the latter. The CCR5delta32 deletion was not associated with fibrosis, fibrosis progression rate, or therapy response. In the view that CCR5 inhibitors are now available for HIV treatment, this is an important observation: our data suggest that these drugs could impair the odds of spontaneous clearance of acute HCV infection in HIV-infected patients on active treatment with anti-CCR5. However drug-induced impairment of CCR5 signaling should neither modify HCV histological outcomes nor impair the efficacy of anti-HCV therapy."